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This section covers common questions about the dosage of Viagra. Across all trials, VIAGRA improved the erections of 43% of radical prostatectomy patients compared to 15% on placebo. One-third to one-half of the subjects in these studies reported successful intercourse at least once during a 4-week, treatment-free run-in period. There was no impairment of fertility in rats given sildenafil up to 60 mg/kg/day for 36 days to females and 102 days to males, a dose producing an AUC value of more than 25 times the human male AUC. In a study of healthy male volunteers, sildenafil (100 mg) did not affect the steady state pharmacokinetics of the HIV protease inhibitors, saquinavir and ritonavir, both of which are CYP3A4 substrates. In healthy male volunteers, there was no evidence of a clinically significant effect of azithromycin (500 mg daily for 3 days) on the systemic exposure of sildenafil or its major circulating metabolite.
Taking Viagra or any other erectile dysfunction medication isn’t something to be ashamed of. Confiding in your partner and involving them on your journey might help, especially as you’ll need to be sexually stimulated for Viagra to work. Sildenafil is the active ingredient in Viagra and the generic version.
Stronger CYP3A4 inhibitors such as ketoconazole and itraconazole would be expected to have greater effects. Studies with human platelets indicate that sildenafil potentiates the antiaggregatory effect of sodium nitroprusside in vitro. There is no safety information on the administration of sildenafil to patients with bleeding disorders or active peptic ulceration. Therefore sildenafil should be administered to these patients only after careful benefit-risk assessment. For some females with HDSS, Addyi can improve sexual desire and increase the number of sexually satisfying events.
This medicine may be used for other purposes