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These tails are topic to several submit-translational covalent modifications, including acetylation, phosphorylation, ubiquitination, sumoylation and methylation (reviewed in 1 ).
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The exception to the rule is the DOT1 family, members of which methylate K79 within the globular area of histone H3 and which are structurally not associated to SET-area proteins 4 - 6 Recent work means that SET-area-containing proteins methylate a couple of proteins in addition to histones (see later)
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